In the wake of all the failed trials with anti amyloid-beta agents, I will say this for the record. I have read the literature, and being a neuropathologist I have seen hundreds of Alzheimer's brains over the years. Nothing else makes sense. If it is really not amyloid-beta, boy we are REALLY screwed.
Who isin't. That stupid experiment is not working, the project you thought was cool is a damp squib after all, the paper is floating in that glossy journal for a year. Stop for a second to think that at the instant you look at these words, a billion neurons are firing, making it possible for you to see, process and understand the words - all in the blink of an eye. And that's just a small fraction of what's working to keep you alive at this instant.
Doing Science was never easy. The truth is that you can only do this if you must, and there is just nothing else you can really do. OK well you can, but at least you need to give this Science thing your best shot.
Some old ones Reposted...
8/18/13 - A Classification of PI's - find yours' in the list!
7/6/12 - Way to a "Science paper"
5/30/11 - 20/20 Hindsights
9/30/11 - Evolution of a bizzare, new Idea
11/17/2011 - Rationale for curiosty-driven research...
lessons from a 4 year old
1/28/12 - "GTFM" - hilarious article on grant writing!
The PI Blog
This blog exists because my wife seemed a bit tired of being the only recipient of my random pontifications on life and Science for many years; and gently encouraged me to vent in a blog instead. From time to time, I put down thoughts that occur to me as I naiively stumble through a life in Science - bestowed upon me by accident (literally!). Please keep in mind that these musings are rather obvious things of little or no use to anyone, and are certainly not personally targeted in any way, even though they are obviously derived from my experiences. OK, enough said.