Subhojit Roy, MD, PhD. Principal Investigator, Fundraiser, Cheerleader, Neuropathologist and elite e-mail forwarder

​UCSD profile: https://profiles.ucsd.edu/subhojit.roy                                           

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I, Subhojit (various pronunciations exist - "soob - oh! - jeet" being the most popular) started life in a small copper mining town in the state of Rajasthan, India, where my father was an engineer. I then went to medical school in Calcutta, India, with every intention to pursue a career in general Medicine. However a series of highly improbable misadventures led me to abandon this predictable path and enter the US (long story). Despite never having held a pipette in medical school (didn't even really know what a pipette was), I decided to do a PhD in neuronal cell biology with Mark Black at Temple (cannot think of a good reason...). Anyway, my thesis work helped resolve a key controversy at that time, and instilled a desire of "finding new things". After a rather intense training-period of residency/fellowship and post-doctoral research in neurodegenerative neuropathology/cell biology with Virginia Lee and John Trojanowski at the ever-vibrant University of Pennsylvania), the Roy Lab was founded in 2008. See my scientific ancestry at Neurotree

A static cell is a dead cell. My broad interest is to explore movement within cells, specifically within neurons - mechanisms that convey, deposit and retain cargoes in axons, dendrites and synapses. Towards this, we are interested in physiologic neuronal transport/trafficking, and also potential abnormalities in these processes in neurodegenerative diseases like Alzheimer's and Parkinson's disease. I am also board-certified in anatomic- and neuro- pathology.
Mailing address:
Subhojit Roy, MD, PhD
Professor, Depts. of Pathology and Neuroscience

email: sroy@ucsd.edu

Jichao Sun ("JC"), PhD. Postdoctoral fellow
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(jsun244 at wisc dot edu)

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Work: work; Hobbies: work

1. Ganguly A, Han X, Das U, Wang L, Loi J, Sun J, Gitler D, Caillol G, Leterrier C, Yates JR 3rd, Roy S. Hsc70 chaperone activity is required for the cytosolic slow axonal transport of synapsin. J Cell Biol. 2017 May 30.

2. Sun J and Roy S. The physical approximation of APP and BACE-1: A key event in Alzheimer's disease pathogenesis. Developmental Neurobiology. 2018 Mar;78(3):340-347.

3. Sun J, Carlson-Stevermer J, Das U, Shen M, Delenclos M, Snead AM, Koo SY, Wang L, Qiao D, Loi J, Petersen AJ, Stockton M, Bhattacharyya A, Jones MV, Zhao X, McLean PJ, Sproul AA, Saha K, Roy S. CRISPR/Cas9 editing of APP C-terminus attenuates β-cleavage and promotes α-cleavage. . Nature Communications. 2019 Jan 3;10(1):53. PMID: 30604771. 

4. Sun J, Wang L, Bao H, Premi S, Das U, Chapman ER, Roy S. Functional cooperation of α-synuclein and VAMP2 in synaptic vesicle recycling. Proc Natl Acad Sci U S A. 2019 May 20. pii: 201903049. doi: 10.1073/pnas.1903049116. [Epub ahead of print] PubMed PMID: 31110017.

5. Atias M, Tevet Y, Sun J, Stavsky A, Tal S, Kahn J, Roy S, Gitler D. Synapsins regulate α-synuclein functions. Proc Natl Acad Sci U S A. 2019 May 20. pii: 201903054. doi: 10.1073/pnas.1903054116. [Epub ahead of print] PubMed PMID: 31110014.

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Sanjay Premi, PhD. (2019 Alumni, Faculty at Moffitt Cancer Center)


https://moffitt.org/research-science/researchers/sanjay-premi/   

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Sun J, Wang L, Bao H, Premi S, Das U, Chapman ER, Roy S. Functional cooperation of α-synuclein and VAMP2 in synaptic vesicle recycling. Proc Natl Acad Sci U S A. 2019 May 20. pii: 201903049. doi: 10.1073/pnas.1903049116. [Epub ahead of print] PubMed PMID: 311

My life as a Neuropathologist 

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A severely atrophic brain ravaged by Alzheimer's disease Click for a slide presentation. If needed, click here for the accompanying audio (will open in separate windows, ignore first 1:20 of audio)



Pankaj Dubey, PhD. Postdoctoral fellow
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​(pankaj.dubey at wisc dot edu)

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1. Leterrier C, Dubey P and Roy S. The Nano-Architecture of the Axonal Cytoskeleton. Nature Reviews in Neuroscience. 2017 Dec;18(12):713-726

2. Dubey P, Jorgenson K and Roy S. Actin Assemblies in the Axon Shaft - some Open Questions.  Current Opinion in Neurobiology 2018 June. 51:163-67

3. Chakrabarty N*, Dubey P*, Tang Y, Ganguly A, Ladt K, Leterrier C, Jung P and Roy S. (2018). Processive movement of actin by biased polymerization: a new paradigm of axonal transport. In press, Journal of Cell Biology. 2018 Nov 6.
​                                                    * Equal contribution

Dianhua Qiao, PhD. Senior Scientist and Lab Manager

Joined Roy lab in 2017
Sun J, Carlson-Stevermer J, Das U, Shen M, Delenclos M, Snead AM, Koo SY, Wang L, Qiao D, Loi J, Petersen AJ, Stockton M, Bhattacharyya A, Jones MV, Zhao X, McLean PJ, Sproul AA, Saha K, Roy S. CRISPR/Cas9 editing of APP C-terminus attenuates β-cleavage and promotes α-cleavage. . Nature Communications. 2019 Jan 3;10(1):53. PMID: 30604771. ​