ALUMNI (and their publications from Roy lab)
Nidhi Checka (undergrad, staff research associate) - medical student at St. Louis University, St. Louis, MO
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Long term rescue of Alzheimer’s deficits in vivo by one-time gene-editing of App C-terminus.
Brent D. Aulston, Kirstan Gimse, Hannah O. Bazick, Eniko A. Kramar, Donald P. Pizzo, Leonardo A. Parra-Rivas, Jichao Sun, Kristen Branes-Guerrero, Nidhi Checka, Neda Bagheri, Nihal Satyadev, Jared Carlson-Stevermer, Takashi Saito, Takaomi C. Saido, Anjon Audhya, Marcelo A. Wood, Mark J. Zylka, Krishanu Saha, and Subhojit Roy* https://www.biorxiv.org/content/10.1101/2024.06.08.598099v1.full |
Veronica Cerada, PhD (postdoc) Freelancing in Brazil
1. Parra-Rivas LA, Madhivanan K, Aulston BD, Wang L, Prakashchand DD, Boyer NP, Saia-Cereda VM, Branes-Guerrero K, Pizzo DP, Bagchi P, Sundar VS, Tang Y, Das U, Scott DA, Rangamani P, Ogawa Y, Subhojit Roy. Serine-129 phosphorylation of α-synuclein is an activity-dependent trigger for physiologic protein-protein interactions and synaptic function. Neuron. 2023 Dec 20;111(24):4006-4023.e10. doi: 10.1016/j.neuron.2023.11.020. PMID: 38128479.
Kayal Madhivanan, PhD (postdoc). Senior Scientist at Arrowhead Pharmaceuticals, San Diego
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1. Stavsky A*, Parra-Rivas LA*, Tal S, Riba J, Madhivanan K, Roy S, Gitler D. Synapsin E-domain is essential for α-synuclein function. bioRxiv [Preprint]. 2023 Dec 7:2023.06.24.546170. doi: 10.1101/2023.06.24.546170. PMID: 37425805.
(* co-first authors) 2. Parra-Rivas LA*, Madhivanan K*, Aulston BD, Wang L, Prakashchand DD, Boyer NP, Saia-Cereda VM, Branes-Guerrero K, Pizzo DP, Bagchi P, Sundar VS, Tang Y, Das U, Scott DA, Rangamani P, Ogawa Y, Subhojit Roy. Serine-129 phosphorylation of α-synuclein is an activity-dependent trigger for physiologic protein-protein interactions and synaptic function. Neuron. 2023 Dec 20;111(24):4006-4023.e10. doi: 10.1016/j.neuron.2023.11.020. PMID: 38128479. (* co-first authors) |
Kristen Branes-Guerrero (staff research associate) Biologist, Eli Lilly, San Diego
Parra-Rivas LA*, Madhivanan K*, Aulston BD, Wang L, Prakashchand DD, Boyer NP, Saia-Cereda VM, Branes-Guerrero K, Pizzo DP, Bagchi P, Sundar VS, Tang Y, Das U, Scott DA, Rangamani P, Ogawa Y, Subhojit Roy. Serine-129 phosphorylation of α-synuclein is an activity-dependent trigger for physiologic protein-protein interactions and synaptic function. Neuron. 2023 Dec 20;111(24):4006-4023.e10. doi: 10.1016/j.neuron.2023.11.020. PMID: 38128479.
Jichao Sun (aka "JC" or "the Beast"), PhD (postdoc). Associate Professor at Shenzhen University Hospital, China
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1. Sun J and Roy S. Gene based therapies for neurodegenerative diseases. Nature Neuroscience, Feb 2021 (review).
2. Sun J, Wang L, Bao H, Premi S, Das U, Chapman ER, Roy S. Functional cooperation of α-synuclein and VAMP2 in synaptic vesicle recycling. Proc Natl Acad Sci U S A. 2019 May 20. pii: 201903049. doi: 10.1073/pnas.1903049116. [Epub ahead of print] PubMed PMID: 31110017. 3. Atias M, Tevet Y, Sun J, Stavsky A, Tal S, Kahn J, Roy S, Gitler D. Synapsins regulate α-synuclein functions. Proc Natl Acad Sci U S A. 2019 May 20. pii: 201903054. doi: 10.1073/pnas.1903054116. [Epub ahead of print] PubMed PMID: 31110014.1. Ganguly A, Han X, Das U, Wang L, Loi J, Sun J, Gitler D, Caillol G, Leterrier C, Yates JR 3rd, Roy S. Hsc70 chaperone activity is required for the cytosolic slow axonal transport of synapsin. J Cell Biol. 2017 May 30. 4. Sun J and Roy S. The physical approximation of APP and BACE-1: A key event in Alzheimer's disease pathogenesis. Developmental Neurobiology. 2018 Mar;78(3):340-347. 5. Sun J, Carlson-Stevermer J, Das U, Shen M, Delenclos M, Snead AM, Koo SY, Wang L, Qiao D, Loi J, Petersen AJ, Stockton M, Bhattacharyya A, Jones MV, Zhao X, McLean PJ, Sproul AA, Saha K, Roy S. CRISPR/Cas9 editing of APP C-terminus attenuates β-cleavage and promotes α-cleavage. . Nature Communications. 2019 Jan 3;10(1):53. PMID: 30604771. |
Archan Ganguly, PhD (postdoc). Assistant Professor (tenure-track), University of Rochester Medical Center
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1. Das U, Scott DA, Ganguly A, Koo EH, Tang Y, Roy S. Neuron. 2013 Aug 7;79(3):447-60.
2. Tang Y, Scott D, Das U, Gitler D, Ganguly A, and Roy S. (2013) Fast vesicle transport is required for the slow axonal transport of synapsin. Journal of Neuroscience, 33(39):15362-15375. 3. Ganguly, A and Roy S (2014). Using Photoactivatable GFP to Track Axonal Transport Kinetics. Methods Mol Biol.;1148:203-15. 4. Ganguly A, Tang Y, Wang L, Ladt K, Loi J, Dargent D, Leterrier C, and Roy S. (2015) A dynamic formin-dependent deep F-actin network in axons. Journal of Cell Biology, July 27 issue; 210(3). 5. Ladt K, Ganguly A, and Roy S. (2015) Actin in action: Imaging actin dynamics in neurons. Methods in Cell Biology (http://dx.doi.org/10.1016/bs.mcb.2015.07.003) 6. Das U, Wang L, Ganguly A, Saikia JM, Wagner SL, Koo EH, Roy S. Visualizing APP and BACE-1 approximation in neurons yields insight into the amyloidogenic pathway. Nat Neurosci. 2015 Dec 7. doi: 10.1038/nn.4188. 7. Ganguly A, Han X, Das U, Wang L, Loi J, Sun J, Gitler D, Caillol G, Leterrier C, Yates JR 3rd, Roy S. Hsc70 chaperone activity is required for the cytosolic slow axonal transport of synapsin. J Cell Biol. 2017 May 30. 8. Chakrabarty N, Dubey P, Tang Y, Ganguly A, Ladt K, Leterrier C, Jung P, Roy S. Processive flow by biased polymerization mediates the slow axonal transport of actin. J Cell Biol. 2019 Jan 7;218(1):112-124. doi: 10.1083/jcb.201711022. Epub 2018 Nov 6. PubMed PMID: 30401699; PubMed Central PMCID: PMC6314539. 9. Ganguly A*, Sharma R*, Boyer NP, Wernert F, Phan S, Boassa D, Parra L, Das U, Caillol G, Han X, Yates JR 3rd, Ellisman MH, Leterrier C, Roy S. Clathrin packets move in slow axonal transport and deliver functional payloads to synapses. Neuron. 2021 Sep 15;109(18):2884-2901.e7. *co-first authors |
Pankaj Dubey, PhD (postdoc). Currently Postdoctoral Fellow at Queen Mary Institute of London
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1. Leterrier C, Dubey P and Roy S. The Nano-Architecture of the Axonal Cytoskeleton. Nature Reviews in Neuroscience. 2017 Dec;18(12):713-726
2. Dubey P, Jorgenson K and Roy S. Actin Assemblies in the Axon Shaft - some Open Questions. Current Opinion in Neurobiology 2018 June. 51:163-67 3. Chakrabarty N*, Dubey P*, Tang Y, Ganguly A, Ladt K, Leterrier C, Jung P and Roy S. (2018). Processive movement of actin by biased polymerization: a new paradigm of axonal transport. In press, Journal of Cell Biology. 2018 Nov 6. * co-first authors |
Sanjay Premi, PhD (postdoc). Currently faculty at Moffitt Cancer Center: https://moffitt.org/research-science/researchers/sanjay-premi/
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Sun J, Wang L, Bao H, Premi S, Das U, Chapman ER, Roy S. Functional cooperation of α-synuclein and VAMP2 in synaptic vesicle recycling. Proc Natl Acad Sci U S A. 2019 May 20. pii: 201903049. doi: 10.1073/pnas.1903049116. [Epub ahead of print] PubMed PMID: 311
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Dianhua Qiao, PhD (staff). Senior Scientist and Lab Manager at U Wisconsin
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Sun J, Carlson-Stevermer J, Das U, Shen M, Delenclos M, Snead AM, Koo SY, Wang L, Qiao D, Loi J, Petersen AJ, Stockton M, Bhattacharyya A, Jones MV, Zhao X, McLean PJ, Sproul AA, Saha K, Roy S. CRISPR/Cas9 editing of APP C-terminus attenuates β-cleavage and promotes α-cleavage. . Nature Communications. 2019 Jan 3;10(1):53. PMID: 30604771.
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Lina Wang, PhD (postdoc). Currently Associate Principal Scientist at Lundbeck
1. Wang L, Das U, Scott D, Tang Y, McLean P and Roy S. alpha-synuclein multimers cluster synaptic vesicles and attenuate recycling. Current Biology, 2014 Sep 24.(14)01040-9.
2. Ganguly A, Tang Y, Wang L, Ladt K, Loi J, Dargent D, Leterrier C, and Roy S. (2015) A dynamic formin-dependent deep F-actin network in axons. Journal of Cell Biology, July 27 issue; 210(3).
3. Das U, Wang L, Ganguly A, Saikia JM, Wagner SL, Koo EH, Roy S. Visualizing APP and BACE-1 approximation in neurons yields insight into the amyloidogenic pathway. Nat Neurosci. 2015 Dec 7. doi: 10.1038/nn.4188.
4. Ganguly A, Han X, Das U, Wang L, Loi J, Sun J, Gitler D, Caillol G, Leterrier C, Yates JR 3rd, Roy S. Hsc70 chaperone activity is required for the cytosolic slow axonal transport of synapsin. J Cell Biol. 2017 May 30.
5. Sun, J., Wang L, Bao H, Premi S, Das U, Chapman ER, Roy S. Functional cooperation of α-synuclein and VAMP2 in synaptic vesicle recycling. Proc Natl Acad Sci U S A. 2019 May 20. pii: 201903049. doi: 10.1073/pnas.1903049116. [Epub ahead of print] PubMed PMID: 31110017.
2. Ganguly A, Tang Y, Wang L, Ladt K, Loi J, Dargent D, Leterrier C, and Roy S. (2015) A dynamic formin-dependent deep F-actin network in axons. Journal of Cell Biology, July 27 issue; 210(3).
3. Das U, Wang L, Ganguly A, Saikia JM, Wagner SL, Koo EH, Roy S. Visualizing APP and BACE-1 approximation in neurons yields insight into the amyloidogenic pathway. Nat Neurosci. 2015 Dec 7. doi: 10.1038/nn.4188.
4. Ganguly A, Han X, Das U, Wang L, Loi J, Sun J, Gitler D, Caillol G, Leterrier C, Yates JR 3rd, Roy S. Hsc70 chaperone activity is required for the cytosolic slow axonal transport of synapsin. J Cell Biol. 2017 May 30.
5. Sun, J., Wang L, Bao H, Premi S, Das U, Chapman ER, Roy S. Functional cooperation of α-synuclein and VAMP2 in synaptic vesicle recycling. Proc Natl Acad Sci U S A. 2019 May 20. pii: 201903049. doi: 10.1073/pnas.1903049116. [Epub ahead of print] PubMed PMID: 31110017.
Jonathan Loi (undergrad). Currently PhD student at UW-Madison
1. Ganguly A, Tang Y, Wang L, Ladt K, Loi J, Dargent D, Leterrier C, and Roy S. (2015) A dynamic formin-dependent deep F-actin network in axons. Journal of Cell Biology, July 27 issue; 210(3).
2. Ganguly A, Han X, Das U, Wang L, Loi J, Sun J, Gitler D, Caillol G, Leterrier C, Yates JR 3rd, Roy S. Hsc70 chaperone activity is required for the cytosolic slow axonal transport of synapsin. J Cell Biol. 2017 May 30
2. Ganguly A, Han X, Das U, Wang L, Loi J, Sun J, Gitler D, Caillol G, Leterrier C, Yates JR 3rd, Roy S. Hsc70 chaperone activity is required for the cytosolic slow axonal transport of synapsin. J Cell Biol. 2017 May 30
Utpal Das ("Dr. D"), PhD (postdoc), Currently Project Scientist at UCSD
Utpal's publications from Roy lab:
1. Scott D*, Das U*, Tang Y and Roy S. Neuron May 2011 12;70(3):441-54. * Equal contribution
2. Tang Y, Scott D, Das U, Edland S, Radomski K, Koo E and Roy S. Traffic, Feb 2011.
3. Tang Y*, Das U*, Scott D and Roy S. Cytoskeleton Feb 2012. * Equal contribution
4. Das U, Scott D, Ganguly A, Koo E, Tang Y, Roy S. Neuron. 2013 Aug 7;79(3):447-60.
5. Tang Y, Scott D, Das U, Gitler D, Ganguly A, and Roy S. (2013) Fast vesicle transport is required for the slow axonal transport of synapsin. Journal of Neuroscience, 33(39):15362-15375.
6. Wang L, Das U, Scott D, Tang Y, McLean P and Roy S. alpha-synuclein multimers cluster synaptic vesicles and attenuate recycling. Current Biology, 2014 Sep 24.(14)01040-9.
7. Das U, Wang L, Ganguly A, Saikia JM, Wagner SL, Koo EH, Roy S. Visualizing APP and BACE-1 approximation in neurons yields insight into the amyloidogenic pathway. Nat Neurosci. 2015 Dec 7. doi: 10.1038/nn.4188.
8. Ganguly A, Han X, Das U, Wang L, Loi J, Sun J, Gitler D, Caillol G, Leterrier C, Yates JR 3rd, Roy S. Hsc70 chaperone activity is required for the cytosolic slow axonal transport of synapsin. J Cell Biol. 2017 May 30.
9. Ganguly A*, Sharma R*, Boyer NP, Wernert F, Phan S, Boassa D, Parra L, Das U, Caillol G, Han X, Yates JR 3rd, Ellisman MH, Leterrier C, Roy S. Clathrin packets move in slow axonal transport and deliver functional payloads to synapses. Neuron. 2021 Sep 15;109(18):2884-2901.e7. *co-first authors
1. Scott D*, Das U*, Tang Y and Roy S. Neuron May 2011 12;70(3):441-54. * Equal contribution
2. Tang Y, Scott D, Das U, Edland S, Radomski K, Koo E and Roy S. Traffic, Feb 2011.
3. Tang Y*, Das U*, Scott D and Roy S. Cytoskeleton Feb 2012. * Equal contribution
4. Das U, Scott D, Ganguly A, Koo E, Tang Y, Roy S. Neuron. 2013 Aug 7;79(3):447-60.
5. Tang Y, Scott D, Das U, Gitler D, Ganguly A, and Roy S. (2013) Fast vesicle transport is required for the slow axonal transport of synapsin. Journal of Neuroscience, 33(39):15362-15375.
6. Wang L, Das U, Scott D, Tang Y, McLean P and Roy S. alpha-synuclein multimers cluster synaptic vesicles and attenuate recycling. Current Biology, 2014 Sep 24.(14)01040-9.
7. Das U, Wang L, Ganguly A, Saikia JM, Wagner SL, Koo EH, Roy S. Visualizing APP and BACE-1 approximation in neurons yields insight into the amyloidogenic pathway. Nat Neurosci. 2015 Dec 7. doi: 10.1038/nn.4188.
8. Ganguly A, Han X, Das U, Wang L, Loi J, Sun J, Gitler D, Caillol G, Leterrier C, Yates JR 3rd, Roy S. Hsc70 chaperone activity is required for the cytosolic slow axonal transport of synapsin. J Cell Biol. 2017 May 30.
9. Ganguly A*, Sharma R*, Boyer NP, Wernert F, Phan S, Boassa D, Parra L, Das U, Caillol G, Han X, Yates JR 3rd, Ellisman MH, Leterrier C, Roy S. Clathrin packets move in slow axonal transport and deliver functional payloads to synapses. Neuron. 2021 Sep 15;109(18):2884-2901.e7. *co-first authors
Kelsey Ladt (grad student), Currently Medical Student at UCSD
Joined Aug 2014, fresh from another sleepless night...her publications from the Roy lab:
1. Ganguly A, Tang Y, Wang L, Ladt K, Loi J, Dargent D, Leterrier C, and Roy S. (2015) A dynamic formin-dependent deep F-actin network in axons. Journal of Cell Biology, July 27 issue; 210(3).
2. Ladt K, Ganguly A, and Roy S. (2015) Actin in action: Imaging actin dynamics in neurons. Methods in Cell Biology (http://dx.doi.org/10.1016/bs.mcb.2015.07.003)
1. Ganguly A, Tang Y, Wang L, Ladt K, Loi J, Dargent D, Leterrier C, and Roy S. (2015) A dynamic formin-dependent deep F-actin network in axons. Journal of Cell Biology, July 27 issue; 210(3).
2. Ladt K, Ganguly A, and Roy S. (2015) Actin in action: Imaging actin dynamics in neurons. Methods in Cell Biology (http://dx.doi.org/10.1016/bs.mcb.2015.07.003)
Yong Tang (undergrad, staff). Currently Pathology resident at Stanford
Yong's publications from Roy lab:
1. Scott D, Tabarean I, Tang Y, Cartier A, Masliah E, Roy S. Journal of Neuroscience Jun 2010 16;30(24):8083-95.
2. Scott D*, Das U*, Tang Y and Roy S. Neuron May 2011 12;70(3):441-54. * Equal contribution
3. Roy S, Yang Ge, Tang Y and Scott D. (2011). Nature Protocols,Dec 2011
4. Tang Y, Scott D, Das U, Edland S, Radomski K, Koo E and Roy S. Traffic, Feb 2011.
5. Tang Y, Das U, Scott D and Roy S. Cytoskeleton Feb 2012.
6. Das U, Scott DA, Ganguly A, Koo EH, Tang Y, Roy S. Neuron. 2013 Aug 7;79(3):447-60.
7. Tang Y, Scott D, Das U, Gitler D, Ganguly A, and Roy S. (2013) Fast vesicle transport is required for the slow axonal transport of
synapsin. Journal of Neuroscience, 33(39):15362-15375.
8. Wang L, Das U, Scott D, Tang Y, McLean P and Roy S. alpha-synuclein multimers cluster synaptic vesicles and attenuate recycling. Current Biology, 2014 Sep 24.(14)01040-9.
9. Ganguly A, Tang Y, Wang L, Ladt K, Loi J, Dargent D, Leterrier C, and Roy S. (2015) A dynamic formin-dependent deep F-actin network in axons. Journal of Cell Biology, July 27 issue; 210(3).
1. Scott D, Tabarean I, Tang Y, Cartier A, Masliah E, Roy S. Journal of Neuroscience Jun 2010 16;30(24):8083-95.
2. Scott D*, Das U*, Tang Y and Roy S. Neuron May 2011 12;70(3):441-54. * Equal contribution
3. Roy S, Yang Ge, Tang Y and Scott D. (2011). Nature Protocols,Dec 2011
4. Tang Y, Scott D, Das U, Edland S, Radomski K, Koo E and Roy S. Traffic, Feb 2011.
5. Tang Y, Das U, Scott D and Roy S. Cytoskeleton Feb 2012.
6. Das U, Scott DA, Ganguly A, Koo EH, Tang Y, Roy S. Neuron. 2013 Aug 7;79(3):447-60.
7. Tang Y, Scott D, Das U, Gitler D, Ganguly A, and Roy S. (2013) Fast vesicle transport is required for the slow axonal transport of
synapsin. Journal of Neuroscience, 33(39):15362-15375.
8. Wang L, Das U, Scott D, Tang Y, McLean P and Roy S. alpha-synuclein multimers cluster synaptic vesicles and attenuate recycling. Current Biology, 2014 Sep 24.(14)01040-9.
9. Ganguly A, Tang Y, Wang L, Ladt K, Loi J, Dargent D, Leterrier C, and Roy S. (2015) A dynamic formin-dependent deep F-actin network in axons. Journal of Cell Biology, July 27 issue; 210(3).
David Scott (undergrad, staff): Current position - Co-founder, Arbor Biotechnologies - https://arbor.bio/founders/david-scott
David's publications from Roy lab:
1. Scott D, Tabarean I, Tang Y, Cartier A, Masliah E, Roy S. Journal of Neuroscience Jun 2010 16;30(24):8083-
2. Scott D*, Das U*, Tang Y and Roy S. Neuron May 2011 12;70(3):441-54. * Equal contribution
3. Roy S, Yang Ge, Tang Y and Scott D. (2011). Nature Protocols,Dec 2011.
4. Tang Y, Scott D, Das U, Edland S, Radomski K, Koo E and Roy S. Traffic, Feb 2011.
5. Tang Y, Das U, Scott D and Roy S. Cytoskeleton Feb 2012.
6. Scott D and Roy, S. Journal of Neuroscience Jul 25;32(30):10129-35.
7. Das U, Scott DA, Ganguly A, Koo EH, Tang Y, Roy S. Neuron. 2013 Aug 7;79(3):447-60.
8.Tang Y, Scott D, Das U, Gitler D, Ganguly A, and Roy S. (2013) Fast vesicle transport is required for the slow axonal transport of
synapsin. Journal of Neuroscience, 33(39):15362-15375.
9. Wang L, Das U, Scott D, Tang Y, McLean P and Roy S. alpha-synuclein multimers cluster synaptic vesicles and attenuate recycling. Current Biology, 2014 Sep 24.(14)01040-9.
1. Scott D, Tabarean I, Tang Y, Cartier A, Masliah E, Roy S. Journal of Neuroscience Jun 2010 16;30(24):8083-
2. Scott D*, Das U*, Tang Y and Roy S. Neuron May 2011 12;70(3):441-54. * Equal contribution
3. Roy S, Yang Ge, Tang Y and Scott D. (2011). Nature Protocols,Dec 2011.
4. Tang Y, Scott D, Das U, Edland S, Radomski K, Koo E and Roy S. Traffic, Feb 2011.
5. Tang Y, Das U, Scott D and Roy S. Cytoskeleton Feb 2012.
6. Scott D and Roy, S. Journal of Neuroscience Jul 25;32(30):10129-35.
7. Das U, Scott DA, Ganguly A, Koo EH, Tang Y, Roy S. Neuron. 2013 Aug 7;79(3):447-60.
8.Tang Y, Scott D, Das U, Gitler D, Ganguly A, and Roy S. (2013) Fast vesicle transport is required for the slow axonal transport of
synapsin. Journal of Neuroscience, 33(39):15362-15375.
9. Wang L, Das U, Scott D, Tang Y, McLean P and Roy S. alpha-synuclein multimers cluster synaptic vesicles and attenuate recycling. Current Biology, 2014 Sep 24.(14)01040-9.