Tang Y, Scott DA, Das U, Edland SD, Radomski K, Koo EH, Roy S*. Early and selective impairments in axonal transport kinetics of synaptic cargoes induced by soluble amyloid β-protein oligomers. Traffic. 2012 May;13(5):681-93. doi: 10.1111/j.1600-0854.2012.01340.x. Epub 2012 Feb 27. PMID: 22309053; PMCID:
PMC3593673.
https://pubmed.ncbi.nlm.nih.gov/22309053/
Das U, Scott DA, Ganguly A, Koo EH, Tang Y, Roy S*. Activity-induced convergence of APP and BACE-1 in acidic microdomains via an endocytosis-dependent pathway. Neuron. 2013 Aug 7;79(3):447-60. doi:
10.1016/j.neuron.2013.05.035. PMID: 23931995; PMCID: PMC3741682.
https://pubmed.ncbi.nlm.nih.gov/23931995/
Tuszynski MH*, Yang JH, Barba D, U HS, Bakay RA, Pay MM, Masliah E, Conner JM, Kobalka P, Roy S, Nagahara AH. Nerve Growth Factor Gene Therapy: Activation of Neuronal Responses in Alzheimer Disease. JAMA Neurol. 2015 Oct;72(10):1139-47. doi: 10.1001/jamaneurol.2015.1807. PMID: 26302439; PMCID: PMC4944824.
https://pubmed.ncbi.nlm.nih.gov/26302439/
Das U, Wang L, Ganguly A, Saikia JM, Wagner SL, Koo EH, Roy S*. Visualizing APP and BACE-1 approximation in neurons yields insight into the amyloidogenic pathway. Nat Neurosci. 2016 Jan;19(1):55-64. doi: 10.1038/nn.4188. Epub 2015 Dec 7. PMID: 26642089; PMCID: PMC4782935.
https://pubmed.ncbi.nlm.nih.gov/26642089/
McKetney J, Runde RM, Hebert AS, Salamat S, Roy S, Coon JJ*. Proteomic Atlas of the Human Brain in Alzheimer's Disease. J Proteome Res. 2019 Mar 1;18(3):1380-1391. doi: 10.1021/acs.jproteome.9b00004. Epub 2019 Feb 20. PMID:
30735395; PMCID: PMC6480317.
https://pubmed.ncbi.nlm.nih.gov/30735395/
Sun J, Carlson-Stevermer J, Das U, Shen M, Delenclos M, Snead AM, Koo SY, Wang L, Qiao D, Loi J, Petersen AJ, Stockton M, Bhattacharyya A, Jones MV, Zhao X, McLean PJ, Sproul AA, Saha K, Roy S*. CRISPR/Cas9 editing of APP C-terminus attenuates β-cleavage and promotes α-cleavage. Nat Commun. 2019 Jan 3;10(1):53. doi: 10.1038/s41467-018-07971-8. PMID: 30604771; PMCID: PMC6318289.
https://pubmed.ncbi.nlm.nih.gov/30604771/
Review:
Sun J, Roy S*. The physical approximation of APP and BACE-1: A key event in Alzheimer's disease pathogenesis. Dev Neurobiol. 2018 Mar;78(3):340-347. doi: 10.1002/dneu.22556. Epub 2017 Nov 13. PMID: 29106038; PMCID: PMC7336871.
https://pubmed.ncbi.nlm.nih.gov/29106038/
PMC3593673.
https://pubmed.ncbi.nlm.nih.gov/22309053/
Das U, Scott DA, Ganguly A, Koo EH, Tang Y, Roy S*. Activity-induced convergence of APP and BACE-1 in acidic microdomains via an endocytosis-dependent pathway. Neuron. 2013 Aug 7;79(3):447-60. doi:
10.1016/j.neuron.2013.05.035. PMID: 23931995; PMCID: PMC3741682.
https://pubmed.ncbi.nlm.nih.gov/23931995/
Tuszynski MH*, Yang JH, Barba D, U HS, Bakay RA, Pay MM, Masliah E, Conner JM, Kobalka P, Roy S, Nagahara AH. Nerve Growth Factor Gene Therapy: Activation of Neuronal Responses in Alzheimer Disease. JAMA Neurol. 2015 Oct;72(10):1139-47. doi: 10.1001/jamaneurol.2015.1807. PMID: 26302439; PMCID: PMC4944824.
https://pubmed.ncbi.nlm.nih.gov/26302439/
Das U, Wang L, Ganguly A, Saikia JM, Wagner SL, Koo EH, Roy S*. Visualizing APP and BACE-1 approximation in neurons yields insight into the amyloidogenic pathway. Nat Neurosci. 2016 Jan;19(1):55-64. doi: 10.1038/nn.4188. Epub 2015 Dec 7. PMID: 26642089; PMCID: PMC4782935.
https://pubmed.ncbi.nlm.nih.gov/26642089/
McKetney J, Runde RM, Hebert AS, Salamat S, Roy S, Coon JJ*. Proteomic Atlas of the Human Brain in Alzheimer's Disease. J Proteome Res. 2019 Mar 1;18(3):1380-1391. doi: 10.1021/acs.jproteome.9b00004. Epub 2019 Feb 20. PMID:
30735395; PMCID: PMC6480317.
https://pubmed.ncbi.nlm.nih.gov/30735395/
Sun J, Carlson-Stevermer J, Das U, Shen M, Delenclos M, Snead AM, Koo SY, Wang L, Qiao D, Loi J, Petersen AJ, Stockton M, Bhattacharyya A, Jones MV, Zhao X, McLean PJ, Sproul AA, Saha K, Roy S*. CRISPR/Cas9 editing of APP C-terminus attenuates β-cleavage and promotes α-cleavage. Nat Commun. 2019 Jan 3;10(1):53. doi: 10.1038/s41467-018-07971-8. PMID: 30604771; PMCID: PMC6318289.
https://pubmed.ncbi.nlm.nih.gov/30604771/
Review:
Sun J, Roy S*. The physical approximation of APP and BACE-1: A key event in Alzheimer's disease pathogenesis. Dev Neurobiol. 2018 Mar;78(3):340-347. doi: 10.1002/dneu.22556. Epub 2017 Nov 13. PMID: 29106038; PMCID: PMC7336871.
https://pubmed.ncbi.nlm.nih.gov/29106038/