What we are all about: "FINDING SOMETHING NEW"
Das U, Wang L, Ganguly A, Saikia JM, Wagner SL, Koo EH, Roy S (2015). Visualizing APP and BACE-1 approximation in neurons yields insight into the amyloidogenic pathway. Nat Neurosci. 2015 Dec 7 issue
Ganguly A, Tang Y, Wang L, Ladt K, Loi J, Dargent D, Leterrier C, and Roy S (2015). A dynamic formin-dependent deep F-actin network in axons. Journal of Cell Biology, July 27 issue; 210(3).
Wang L, Das U, Scott D, Tang Y, McLean P and Roy S (2014). Alpha-Synuclein Multimers Cluster Synaptic Vesicles and attenuate Recycling. Current Biology, 2014 Sep 24. (14)01040-9.
Tang Y, Scott D, Das U, Gitler D, Ganguly S, and Roy S (2013). Fast vesicle transport is required for the slow axonal transport of synapsin.
Journal of Neuroscience, 33(39):15362-15375.
Das U, Scott D, Koo EH, Tang Y and Roy S. (2013) Activity-induced convergence of APP and BACE-1 in acidic microdomains via an endocytosis-dependent pathway.
Neuron, Aug. 7 issue.
Scott D and Roy S. (2012) Alpha-synuclein inhibits inter-synaptic vesicle mobility and maintains recycling pool homeostasis.
Journal of Neuroscience, July 25; 32(30):10129-35.
Roy S, Yang Ge, Tang Y and Scott D. (2011). A simple photo-activation and image-analysis module for visualizing and analyzing axonal transport with high temporal resolution.
Nature Protocols; 7:62-8.
Scott D, Das U, Tang Y and Roy S. (2011) Mechanistic logic underlying the axonal transport of cytosolic proteins.
Scott D, Tabarean I, Tang Y, Cartier A, Masliah E, Roy S. (2010) A pathologic cascade leading to synaptic dysfunction in α-synuclein-induced neuro-degeneration
Journal of Neuroscience 16;30(24):8083-95.
Tang Y, Scott D, Das U, Edland S, Radomski K, Koo E and Roy
S. (2012) Early and selective impairments in axonal transport kinetics of synaptic cargoes induced by soluble amyloid-beta protein oligomers.
We are generally interested in neuronal trafficking - how things move around in neurons. There are two overall focus areas:
1. Cell Biology of Neuronal trafficking/transport: Due to their complex geometry and finite sites of bulk protein synthesis (perikarya), neurons have evolved elaborate transport and trafficking machinery to deliver proteins into axons and dendrites. How are somatically-synthesized proteins delivered to their appropriate sites, and then retained there (for example at the synaptic terminal)? Knowledge into the biology of this process is critical to our understanding of neuronal form and function.
2. Cell Biology of Neurodegeneration: There is general consensus that that amyloid-beta and tau are key proteins involved in Alzheimer's disease, and that alpha-synuclein is intimately involved in Parkinson's disease (whether they are pathogenic or not). Yet, a major gap in our understanding relates to the precise pathways by which these proteins induce neuronal dysfunction - particularly initiating mechanisms, and how/where the various pathologic proteins operate in a given pathologic cascade. We believe that these questions can be answered by high-fidelity cellular models that accurately capture key pathologic features of these diseases - for example synaptic dysfunction. Below is a generic description of some of the current projects.
Jan 2015 - Short review on axonal actin published in JCB
Dec 2015 - SR co-organizes special interest meeting at ASCB See pic
Dec 2015 - Dr. D's paper published in Nature Neuroscience.
Sept 2015 - Kelsey gets an F30.
Aug 2015 - Our Alzheimer's drug discovery grant funded...new avenue for the lab.
Aug 18, 2015 - Archan's paper one of the top 3 "most-read" papers in JCB..
Aug 2015 - Archan's paper cited in F1000 Link
July 2015 - Archan's magnum opus published in JCB w/ cover and editorial. Safe to say he is happy....see pic
July 2015 - Kelsey and Archan's methods paper accompanying JCB article published. Link
July 2015 - Deanna Ross, STARS student joins us for the summer
July 2015 - Junmi Saikia, MSTP student has a productive summer rotation! Taken under wing by Dr. D....
June 2015 - Lina receives the prestigious Larry Hillblom postdoctoral Fellowship.
May/June 2015 - Subhojit co-organizes neuronal trafficking meeting with Erika Holzbaur and Kang Shen. See pics
Jan 2015 - Amazing life-like portraits on lab wall by Jon (Jon sketched by Kelsey). Sharpie on Polystyrene Foam...PI scowling as expected See pic
Dec 2014 - Lab Camping Trip!
See pics here
Sept 2014 - Lina's paper on alpha-synuclein published in Current Biology. See pic of synuclein party
Sept 2014 - Jonathan Loi (undergrad) joins the lab.
Aug 2014 - Kelsey Ladt, PhD student joins the lab.
Apr 2014 - Archan's paper comes out in "Methods in Molecular Biology".
Apr 2014 - Subhojit gives a talk at Mayo Clinic Jacksonville (invited by Pam McLean).
Apr 2014 - New paper on autistic brains in NEJM (Subhojit is neuropathologist).
Mar 2014 - Subhojit gives a talk at the ASN meeting in Long Beach.
Dec 2013 - The Roy lab travels to the big easy for ASCB meeting. See pics here
Nov 2013- Subhojit gives talks at Columbia and Temple U.
Nov 2013 - Irene Sambri (TIGEM Naples) visits Roy lab for a short training.
Nov 2013 - Lina unleashes her synuclein poster at SFN...
Oct 2013 - Ivonnie Shih, undergrad Regents scholar joins lab for rotation.
Sept/Oct - Dr. D's and Yong's paper recommended in F1000.