Selected publications

Tang Y, Scott D, Das U, Gitler D, Ganguly S, and Roy S (2013). Fast vesicle transport is required for the slow axonal transport of synapsin.
Journal of Neuroscience, 33(39):15362-15375.    

Das U, Scott D, Koo EH, Tang Y and Roy S. (2013) Activity-induced convergence of APP and BACE-1 in acidic microdomains via an endocytosis-dependent pathway.
Neuron, Aug. 7 issue. 

Scott D and Roy S. (2012) Alpha-synuclein inhibits inter-synaptic vesicle mobility and maintains recycling pool  homeostasis.
Journal of Neuroscience, July 25; 32(30):10129-35.
    
Roy S, Yang Ge, Tang Y and Scott D. (2011). A simple photo-activation and image-analysis module for visualizing and analyzing axonal transport with high temporal resolution.
Nature Protocols; 7:62-8.   
 
Scott D, Das U, Tang Y and Roy S. (2011) Mechanistic logic underlying the axonal transport of cytosolic proteins.
Neuron. 70(3):441-54.    
   
Scott D, Tabarean I, Tang Y, Cartier A, Masliah E, Roy S. (2010) A pathologic cascade leading to synaptic dysfunction in α-synuclein-induced neuro-degeneration
Journal of Neuroscience 16;30(24):8083-95.        

Tang Y, Scott D, Das U, Edland S, Radomski K, Koo E and Roy
S. (2012) Early and selective impairments in axonal transport kinetics of synaptic cargoes induced by soluble amyloid-beta protein oligomers.
Traffic, 13(5):681-93.
                                      VISUALIZING SLOW AXONAL TRANSPORT
Visualizing and Analyzing Slow Axonal Transport: A temporally-linked composite showing the mobility of the PAGFP:synapsin (slow transport cargo) after photoactivation in an axon (greyscale, top, direction of axon left --> right); the resultant pseudocolor kymograph in the center (middle); and the intensity-center data below (essentially sequential line-scans; the quantitative center is marked with a red dot to help visualize the shift). Note the shift in the curves (displacement of the red dot) corresponds to the anterogradely-biased transport of the fluorescent plume as seen in the kymograph and the greyscale image. Gaussian curves are shown for ease of visualization, but the data are similar to that from raw intensity-values.
See Roy et al., 2011

       What's New


Apr 2014 - Archan's paper comes out in "Methods in Molecular Biology".

Apr 2014 - Subhojit gives a talk at Mayo Clinic Jacksonville (invited by Pam McLean).

Apr 2014 - New paper on autistic brains in NEJM (Subhojit is neuropathologist).

Mar 2014 - Subhojit gives a talk at the ASN meeting in Long Beach.

Dec 2013 - The Roy lab travels to the big easy for ASCB meeting. See pics here

Nov 2013- Subhojit gives talks at Columbia and Temple U.

Nov 2013 - Irene Sambri (TIGEM Naples) visits Roy lab for a short training.

Nov 2013 - Lina unleashes her synuclein poster at SFN...
Oct 2013 - Ivonnie Shih, undergrad Regents scholar joins lab for rotation.
Sept/Oct - Dr. D's and Yong's paper recommended in F1000.

Sept. 25 2013 - Yong's paper published.

Aug. 14 2013 - Yong's paper on the raison d'etre of slow axonal transport - accepted in J Neurosci (his last hurrah...or is it?) 

Aug 7 2013 - Dr. D's magnum opus finally appears in Neuron (after we have already celebrated it a dozen times)...see pics for the multiple celebs

Aug 2 2013 - Review on Slow Axonal Transport in the Neuroscientist

July 2013 - Flurry in the lab as we make a "video abstract" for Neuron...see pics here