Recent papers (selected)
Clathrin packets move in slow axonal transport and deliver functional payloads to synapses. Ganguly A, and Sharma R et al. Neuron, Sept 2021.
Gene-based therapies for neurodegenerative diseases (review). Sun and Roy, Nature Neuroscience, Feb 2021
Functional cooperation of α-synuclein and VAMP2 in synaptic vesicle recycling. Sun et al., PNAS, <direct submission>. May 2019
Synapsins regulate α-synuclein function. Atias et al., PNAS, <direct submission>. May 2019
CRISPR/Cas9 editing of APP C-terminus attenuates β-cleavage and promotes α-cleavage. Sun et al., Nature Communications, Jan 2019
Processive flow by biased polymerization mediates the slow axonal transport of actin. Chakrabarty et al., Journal of Cell Biology, Jan 2019
The physical approximation of APP and BACE-1: A key event in Alzheimer's disease pathogenesis. Sun J and Roy S. Developmental Neurobiology, Mar 2018
The Nano-Architecture of the Axonal Cytoskeleton. Leterrier C, Dubey P and Roy S. Nature Reviews in Neuroscience , Dec 2017
Hsc70 chaperone activity is required for the cytosolic slow axonal transport of synapsin. Ganguly et al., Journal of Cell Biology. July 2017
Visualization of APP and BACE-1 approximation in neurons: new insights into the amyloidogenic pathway. Das et al., Nature Neuroscience, Jan 2016
A dynamic formin-dependent deep F-actin network in axons. Ganguly et al., Journal of Cell Biology, Aug 2015
α-Synuclein Multimers Cluster Synaptic Vesicles and Attenuate Recycling. Wang et al., Current Biology, Oct 2014
Activity-induced convergence of APP and BACE-1 in acidic microdomains via an endocytosis-dependent pathway. Das et al., Neuron, Aug 2013
Fast vesicle transport is required for the slow axonal transport of synapsin. Tang et al., Journal of Neuroscience, Sept 2013
Welcome to the Roy Lab
A static cell is a dead cell. Our broad interest is to explore movement in neurons – mechanisms that convey, deposit, and retain cargoes in axons, dendrites and synapses. A related interest is to manipulate trafficking-pathways for therapeutics in neurodegenerative diseases (particularly gene- and CRISPR- based therapies).
Mar 2022: Rohan's new baby in lab alert.
Feb 2022 - Our review on gene therapy and gene editing for neurodegeneration highlighted in Nature collections: https://www.nature.com/collections/ajadgefeih
Jan 2022 - Transformative $50M gift to UCSD and USC will support Alzheimer's research, including potential CRISPR therapies pursued by our lab. UCSD press release: https://ucsdnews.ucsd.edu/pressrelease/with-a-50-million-gift-usc-and-uc-san-diego-join-forces-in-alzheimers-research
Dec 2021 - We welcome two new postdocs - Veronica and Tamara.
Nov 2021 - Subhojit gives zoom talk on Alzheimer's gene therapy at Neuroupdate, Kolkata https://www.iicb.res.in/news/neuroupdate-conference-on-november-27-28-2021
Oct 2021 - New collaborative grant from ASAP, led by V. Gradinaru at Caltech: https://www.caltech.edu/about/news/caltech-researchers-team-up-to-fight-parkinsons-disease
Sept 2021 - Our "clathrin packet" paper highlighted in Nature Reviews in Neuroscience "Delivering Clathrin": https://www.nature.com/articles/s41583-021-00529-6
Sept 2021 - New paper on clathrin: https://www.cell.com/neuron/fulltext/S0896-6273(21)00613-9www.cell.com/neuron/fulltext/S0896-6273(21)00613-9
July 2021 - Archan and Rohan et al. paper on clathrin transport and synaptic targeting accepted in Neuron.
July 2021 - Lab awarded a Foundation grant to work on CRISPR therapies for Parkinson's disease.
July 2021 - Leo awarded a postdoctoral fellowship from the American Parkinson's Disease Association (APDA).
June 2021 - Nihal Satyadev (medical student) joins lab as part of NIA-funded Medical Student Training in Aging Research (MSTAR) scholarship program
May 2021 - Subhojit presents Brent APP-editing work at the SCGE (Somatic Cell Genome Editing) consortium annual meeting.
April 2021 - Perspective on SCGE (Somatic Cell Genome Editing) published in Nature: https://www.nature.com/articles/s41586-021-03191-1
March 2021 - Subhojit presents Archan and Rohan's clathrin work at the annual German Neuroscience Society meeting.
Feb 2021 - Jichao and Subhojit's review on gene therapy and neurodegeneration published in Nature Neuroscience: https://www.nature.com/articles/s41593-020-00778-1
Jan 2021 -Brent awarded a postdoctoral training fellowship on Alzheimer's disease (T32).