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The images above represents four key elements of our scentific endeavors. Top Right: An imaginary view of Fast and Slow axonal transport. Membranous organelles move in fast transport as persistent, individual vesicles (linear tracks from real APP:YFP kymograph shown), while cytosolic proteins have a peculiar biased streaming motion (a real synapsin kymograph shown), Read our paper. Top Left: An experimentally-tractable model-system of Parkinson's disease pathology. David's artistic view of alpha-synuclein (green) and dendrites (MAP2, red) as one meanders through the brains of our alpha-synuclein:GFP transgenic mice, Read our paper. Bottom Left: Computational simulation of cytosolic slow axonal transport.  Biased slow axonal transport of a pool of a cytosolic protein (green), transiently associating with the yet elusive "mobile units" (linear and persistent red streaks). Bottom Right: A yeast cell expressing alpha-synuclein with large vesicular aggregates- a lesson from evolution or an artifact in yeast? Read the paper