Selected publications

Tang Y, Scott D, Das U, Gitler D, Ganguly S, and Roy S (2013). Fast vesicle transport is required for the slow axonal transport of synapsin.
Journal of Neuroscience, 33(39):15362-15375.    

Das U, Scott D, Koo EH, Tang Y and Roy S. (2013) Activity-induced convergence of APP and BACE-1 in acidic microdomains via an endocytosis-dependent pathway.
Neuron, Aug. 7 issue. 

Scott D and Roy S. (2012) Alpha-synuclein inhibits inter-synaptic vesicle mobility and maintains recycling pool  homeostasis.
Journal of Neuroscience, July 25; 32(30):10129-35.
    
Roy S, Yang Ge, Tang Y and Scott D. (2011). A simple photo-activation and image-analysis module for visualizing and analyzing axonal transport with high temporal resolution.
Nature Protocols; 7:62-8.   
 
Scott D, Das U, Tang Y and Roy S. (2011) Mechanistic logic underlying the axonal transport of cytosolic proteins.
Neuron. 70(3):441-54.    
   
Scott D, Tabarean I, Tang Y, Cartier A, Masliah E, Roy S. (2010) A pathologic cascade leading to synaptic dysfunction in α-synuclein-induced neuro-degeneration
Journal of Neuroscience 16;30(24):8083-95.        

Tang Y, Scott D, Das U, Edland S, Radomski K, Koo E and Roy
S. (2012) Early and selective impairments in axonal transport kinetics of synaptic cargoes induced by soluble amyloid-beta protein oligomers.
Traffic, 13(5):681-93.
Picture
The images above represents four key elements of our scientific endeavors. Top Right: An imaginary view of Fast and Slow axonal transport. Membranous organelles move in fast transport as persistent, individual vesicles (linear tracks from real APP:YFP kymograph shown), while cytosolic proteins have a peculiar biased streaming motion (a real synapsin kymograph shown), Read our paper. Top Left: An experimentally-tractable model-system of Parkinson's disease pathology. David's artistic view of alpha-synuclein (green) and dendrites (MAP2, red) as one meanders through the brains of our alpha-synuclein:GFP transgenic mice, Read our paper. Bottom Left: Computational simulation of cytosolic slow axonal transport.  Biased slow axonal transport of a pool of a cytosolic protein (green), transiently associating with the yet elusive "mobile units" (linear and persistent red streaks). Bottom Right: A yeast cell expressing alpha-synuclein with large vesicular aggregates- a lesson from evolution or an artifact in yeast? Read the paper  

       What's New

Nov 2013 - Lina unleashes her synuclein poster at SFN...
Oct 2013 - Ivonnie Shih, undergrad Regents scholar joins lab for rotation.
Sept/Oct - Dr. D's and Yong's paper recommended in F1000.

Sept. 25 2013 - Yong's paper published.

Aug. 14 2013 - Yong's paper on the raison d'etre of slow axonal transport - accepted in J Neurosci (his last hurrah...or is it?) 

Aug 7 2013 - Dr. D's magnum opus finally appears in Neuron (after we have already celebrated it a dozen times)...see pics for the multiple celebs

Aug 2 2013 - Review on Slow Axonal Transport in the Neuroscientist

July 2013 - Flurry in the lab as we make a "video abstract" for Neuron...see pics here

July 2013 - Kelsey Ladt (MD/PhD student) joins us for a rotation.

June 2013 - Yong Tang leaves to
start his MD/PhD program at Stanford this fall. Good luck Yong, you will be missed.

June 2013 - Talk at TIGEM Naples
Subhojit gave a talk at TIGEM, Naples. Invited by Alessandro Fraldi.
 
May 2013 - Utpal Das (Dr. D)'s paper accepted in Neuron. Congratulations Dr. D! 

May 2013 - David Adamowicz(MD/PhD student) gets a summer fellowship from the American Parkinson's disease Association. Congratulations!

April 2013 - Talk at the Huntington's disease symposium
Invited talk by Subhojit at Keck Graduate Institute 3rd Annual Research Symposium:
Huntington's Disease: From Basic Science to Therapy

March 2013 - AD/PD meeting, Florence ADPD meeting
(Florence): Subhojit gave a talk on Utpal Das' work on APP/BACE1
trafficking. See pics in "lab photos"   

Jan 2013 - M2T2 meeting, India
Advanced School and meeting on "Axonal transport and Neuro-degeneration" in Mumbai and scenic Mahabaleshwar (India), co-organized by Dr. Roy:
https://www.icts.res.in/program/
current/details/329/