The Roy Lab is growing, and has immediate openings for two post-doctoral fellows (see advertisement below). We are also keen to have motivated Ph.D. students join our lab. Contact Dr. Roy for rotations: roy27@wisc.edu
Postdoctoral Scholars in Cell Biology of Neuronal Trafficking
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Two postdoctoral positions are available in the Roy lab at the University of Wisconsin-Madison. The selected candidate(s) will have considerable freedom to operate and develop their research career. They can either lead promising ongoing projects, or initiate and develop independent research projects within the broad realm of neuronal transport and trafficking. Candidate will receive active feedback and guidance in experimental planning, data presentation, manuscript writing, and development of grant proposals, as applicable. It is expected that the candidate would develop an outstanding publication record (for publications of previous trainees from the Roy lab, see http://www.roylab.org/people.html).
A general approach in the lab is to develop simple cellular models of normal and abnormal biological phenotypes – using dissociated neurons, 3-D organoids, and induced pluripotent stem cells (iPSC's) – and test predictions from these models in brains. Key publications using this approach are listed below, for a full list please see: http://www.roylab.org/publications.html. Current projects include novel uses of CRISPR-Cas9 technology in cellular model-systems of neurodegenerative diseases, optogenetic approaches to study slow axonal transport, and use of iPSC’s to explore human cell biology. The lab has ongoing collaborations with researchers at the Wisconsin Institute for Discovery (WID), the Waisman Center, and other investigators at UW-Madison; and is located on modern, state of the art laboratory and office space overlooking lake Mendota (within the Wisconsin Institute for Medical Research or WIMR-II tower: WIMR-II-science-without-walls). Requirements: The candidate must be motivated to pursue basic biomedical research and have a desire to discover new things. S/he should have a doctorate degree in cell/molecular biology or a relevant area with at least one major publication (regular journals or biorxiv). Experience in molecular biology, advanced light microscopy and live imaging is desirable. The candidate must be able to work collegially with others, and is expected to hold themselves to the highest ethical standards. Women, minorities, and disadvantaged candidates are particularly encouraged to apply. Salary: NIH standard based upon experience + relocation expenses. To apply, send CV and names/contact information of three references to roy27@wisc.edu. Selected Publications: Das U, Wang L, Ganguly A, Saikia J, Wagner SL, Koo EH and Roy S. (2016) Visualization of APP and BACE-1 approximation in neurons: new insights into the amyloidogenic pathway. Nature Neuroscience, Jan;19(1):55-64. PMID: 26642089 Ganguly A, Tang Y, Wang L, Ladt K, Loi J, Dargent D, Leterrier C, and Roy S. (2015) A dynamic formin-dependent deep F-actin network in axons. Journal of Cell Biology, Aug 3 issue; 210(3): 401-17. PMID: 26216902 Wang L, Das U, Scott DA, Tang Y, McLean PJ, Roy S. (2014) α-Synuclein Multimers Cluster Synaptic Vesicles and Attenuate Recycling. Current Biology 24(19):2319-26. PMID: 25264250 Das U, Scott D, Koo EH, Tang Y and Roy S. (2013) Activity-induced convergence of APP and BACE-1 in acidic microdomains via an endocytosis-dependent pathway. Neuron, 79(3):447-60. PMID: 23931995. Scott D, Das U, Tang Y and Roy S. (2011) Mechanistic logic underlying the axonal transport of cytosolic proteins. Neuron, 70(3):441-54. PMID: 21555071 |
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